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What causes Peyronies's Disease?

At present, the actual mechanism causing Peyronie’s disease is still unknown. It is suspected that this condition occurs in the genetically predisposed patient following a trauma to the erect penis. Possibly patients with Peyronie’s Disease present an imbalance in the factors promoting the healing process after a trauma and this leads to excessive local tissue proliferation following a trauma.

Typically Peyronie’s Disease presents an initial acute and a chronic phase. The acute phase is characterized by the formation of the plaque, which is tender at palpation as there is an active local inflammatory process.
During this phase, stretching of the plaques, as physiologically occurs during erections, elicits vivid pain.

Plaque size and type of deformity tend to change over time during this phase. The chronic phase starts when the inflammatory process eventually settles, usually around 3 to 9 months from the onset of the condition. At this stage the pain generally settles and the deformity stabilizes. 

Peyronie's disease can present with 1 or more of the following:
  • Painful erection
  • A lump in the penis
  • Penile shortening
  • Penile curvature during erection
  • Penile indentation or hour glass deformity
  • Weak erection
  • Significant psychologial distress to both patient and partner
Talk to a specialist about treatment and options

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St Peters Andrology is the first centre in the UK to offer Collagenase (Xiapex) treatment for Peyronies disease.  Get in contact with us to arrange an appointment.  

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