At present, the actual mechanism causing Peyronie’s disease is still unknown. It is suspected that this condition occurs in the genetically predisposed patient following a trauma to the erect penis. Possibly patients with Peyronie’s Disease present an imbalance in the factors promoting the healing process after a trauma and this leads to excessive local tissue proliferation following a trauma.
Typically Peyronie’s Disease presents an initial acute and a chronic phase. The acute phase is characterized by the formation of the plaque, which is tender at palpation as there is an active local inflammatory process.
During this phase, stretching of the plaques, as physiologically occurs during erections, elicits vivid pain.